Hormonal effects of flutamide in young women with polycystic ovary syndrome.
نویسندگان
چکیده
Anovulation in women with polycystic ovary syndrome (PCOS) is the direct effect of high local androgen concentrations on the ovary. Antiandrogens are substances that prevent androgens from expressing their activity on target tissues. Flutamide is a nonsteroid antiandrogen that has been found effective in hirsute patients, although its mechanism of action is unclear. Eight girls, ranging in age from 16-19 yr, with moderate to severe hirsutism and menstrual irregularities were enrolled in this study. The basal hormonal pattern showed anovulatory cycles; increased concentrations of LH, androstenedione, and testosterone; and increased LH/FSH ratio. A baseline ultrasound scan revealed polycystic ovaries in all patients. All were given 250 mg flutamide twice a day for 6 months. LH, FSH, androstenedione, testosterone, estradiol, and progesterone were evaluated before treatment, every 4 days during the third month of treatment, and on day 24 of the sixth month of treatment. Hirsutism improved, androgen levels dropped, and ovulatory cycles were restored in all subjects. Ultrasonographic examination in follicular phase showed a significant reduction in ovarian volume and ovaries of normal appearance with one dominant follicle. The most important result of the present study was that flutamide restored ovulation in anovulatory PCOS patients. This finding supports the hypothesis that flutamide reduces androgen synthesis through restoration of ovulation, although a direct block of the steroidogenic enzymes of androgen biosynthesis in ovarian thecal cells cannot be excluded.
منابع مشابه
Prevalence and hormonal profile of polycystic ovary syndrome in young Kashmiri women presenting with hirsutism: A hospital based study
Background: Hirsutism, a common clinical condition, not onlycauses cosmetic concern but may also be a sign of underlyingdisease. Polycystic ovary syndrome (PCOS) is an importantand common cause of hirsutism. In fact, many women withPCOS present as hirsutism. This study assessed young Kashmiriwomen presenting as hirsutism, for ultrasonographic evidence ofpolycystic ovaries (PCO), in addition to ...
متن کاملEffect of Aerobic Training Program on Obesity and Insulin Resistance in Young Women with Polycystic Ovary Syndrome
OBJECTIVE: Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age characterized by the presence of polycystic ovaries, menstrual dysfunction and biochemical or clinical hyperandrogenism. Lifestyle modification is important in treatment of obese and overweight women with PCOS. This study was performed to evaluate the benefit of aerobic exercise training o...
متن کامل[Effectiveness of flutamide alone or combined with oral contraceptives in the treatment of hirsutism in women].
BACKGROUND Flutamide is an antiandrogen devoid of other hormonal effects, except for a decrease in the secretion of adrenal androgens such as dehydroepidandrosterone sulphate (DHEA-s) and androstenedione. AIM To assess the effectiveness of flutamide in the treatment of hirsutism, used as monotherapy or combined with oral contraceptives (OC). PATIENTS AND METHODS Women with peripheral hirsut...
متن کاملPathophysiological mechanisms of gonadotropins– and steroid hormones–related genes in etiology of polycystic ovary syndrome
Objective(s): Polycystic ovary syndrome (PCOS) is an endocrinopathy in women, which, unlike its impact on fertility and health of women, there is no clear understanding about the causal mechanisms of this pathogenesis. The aim of this review paper is to investigate the pathophysiological pathways affecting the PCOS etiology, based on functions of gonadotropins– and steroid hormones–related gene...
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ورودعنوان ژورنال:
- The Journal of clinical endocrinology and metabolism
دوره 83 1 شماره
صفحات -
تاریخ انتشار 1998